- Small-bowel mucosal permeability and mucosal immune activation have been identified as factors typically associated with IBS-D5
- There is evidence that low-grade inflammation plays a key role in IBS-related enteropathy—and that mast cell activation may be an important factor 6-8
- Mast cells are in close proximity to intestinal neurons, and studies demonstrate that mast cell mediators may influence intestinal motility in IBS6-8
Please see full Important Safety Information in Safety section and
full Prescribing Information including contraindications in PI section.
full Prescribing Information including contraindications in PI section.